PEGylated Proteins Market Share, Trends, Analysis, Growth and Opportunities 2017 to 2022

PEGylated Proteins Market
PEGylated Proteins Market

PEGylated proteins come in handy in augmenting drug potency by its half-life and offer a convenient cover from protein enzymatic degradation. Profound spending on the part of pharmaceutical and biotechnology companies in R&D investments, growth in biologics sector and incessant spread of lifestyle diseases is a market driver to PEGylated protein market. Restraints observed in PEGylated Proteins Market include unresponsiveness and frugality of observed market coupled with product-recall. Increasing market for protein-based drugs over non-protein drugs is driver to growth of PEGylated proteins market. Segmentation of PEGylated proteins market by product includes consumables, PEGylation kits and services. Segmentation of PEGylated proteins market by protein type constitute colony stimulating factors, interferons, erythropoietin, mAbs, recombinant factor VIII and other protein type.

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By application, PEGylated proteins industry comprises cancer treatment, hepatitis, chronic kidney diseases, hemophilia, multiple sclerosis, gastrointestinal disorders and other applications. By end-user, markets comprise pharmaceutical and biotechnology companies, CRO’s and academic research institutes. By geography, market size comprises North America, Europe, Asia pacific, MEA and Latin America. Consumable product segment accounted for large share in market revenue in PEGylated proteins industry. Growth in PEGylated proteins market is attributed to marked adoption of monoclonal antibodies, erythropoietin and interferon for treatment of chronic diseases and large-scale funding by government and grants for research.

As per news, big growth in PEGylated proteins industry is projected owing to growing government favors and collaborations between foreign bodies and local players in the region. Asia Pacific has turned into a favorable market for many big biopharma players who are setting base in Asia pacific markets with investments on a large scale in R&D wing. New reagents such as biodegradable polymers, PEG linkers offer a huge market by providing impetus in ongoing research of drug delivery technology due to capability in providing a biomaterial having amphiphilic properties.

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Increasing applications of PEGylated proteins in treating cancer, blood disorder, and chronic disease are prominent factors in PEGylated proteins market. Increasing application of new products including PEGylation reagents and kits is an area of focus in many emerging countries. North America exhibited maximum growth in PEGylated protein industry with Asia pacific constituting emerging market for PEGylated proteins industry. As per news, PEGylation is a drug delivery technique that displays association of polyethylene glycol chains (PEG) to a therapeutic protein, peptide or non-peptide molecule. PEG reagents form covalent bonds to find application in oncology, blood disorders, chronic and auto immune diseases and chronic diseases. Key players include Merck Millipore, Thermo Fischer Scientific, NOF Corporation, JenKem Technology, Creative PEGworks, Celares GmbH, Quanta Biodesign, Biomatrik, Inc., Iris Biotech GmbH, Laysan Bio, Ltd.

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

  • Colony Stimulating Factors
  • Interferons
  • Erythropoietin (EPO)
  • Recombinant Factor Viii
  • Monoclonal Antibodies
  • Others

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of PEGylated Proteins for each application, including

  • Cancer Treatment
  • Hepatitis
  • Chronic Kidney Disease
  • Leukemia
  • SCID
  • Rheumatoid Arthritis & Crohn’s Disease
  • Others

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Nylon Resins Market Share, Size, Analysis, Growth and Forecast Report to 2022

Nylon is particularly a thermoplastic silky material and was first used in a nylon-bristled toothbrush. Nylon is also known as polyamide; which describes a family of polymers that are featured by the presence of amide groups. Polyamides are mostly aliphatic, linear polymers of the amide group. The condensation product of amine and carboxylic acid in the polymer chain is thus separated by hydrocarbon unit. On the basis of end-user industry, the Global Nylon Resins Market is segmented into automotive, electrical and electronics, aerospace and defense, extrusion and textile, packaging and storage.

Nylon Resins Market
Nylon Resins Market

Nylon offers good wear and tear along with high density and highly elastic. Also, it possesses a high impact resistance, a heat distortion temperature, resist wear, abrasion and vibration. Nylon resin being the first commercial synthetic polymer is used in carpet fiber, apparel, airbags, tires, ropes and conveyor belts, etc. Nylon can thus be used as a matrix material in composite materials coupled with fibers like glass which possesses a higher density than pure nylon.  On a commercial level, Nylon 66 offers higher stability against high temperatures and volatile chemicals. Nylon 6 is another element which when added with silica sand and minerals that enhances the strength & temperature resistivity of glass fibers. Nylon resin is particularly prepared by pre-processing, extrusion and film forming methods. The better way to classify polymers (Nylon) is firmly based on mechanical and thermal behavior.

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Plastics and elastomers are industrially classified polymers, thus plastics are moldable organic resins which are either natural or synthetic and are administered by molding it into various shapes and forms. Further, the specific use of nylon resin depends on polymer crystallization which defines the properties and kind of end product. Overall, the market growth for nylon resins coupled between market dynamics and driving factors witnesses a higher CAGR during the forecast period.  The key driving factors responsible for the growth of nylon resins market includes growth in use of bio-based nylons and augmenting demand for fuel efficient and lightweight vehicles worldwide and offers lucrative opportunities and immense potential. However, the price fluctuations in the raw material prices are likely to impede the market growth for nylon resins.

On the basis of geographic segmentation, the global nylon resins market spans North America, Latin America, Europe, Asia-Pacific, Middle-East and Africa. APAC regions dominate the global market and are anticipated to grow at a higher CAGR during the forecast period. North American market is anticipated to grow at a higher CAGR during the forecast period owing to growth in end-user application industries. The key players in the global nylon resins market include Aquafill USA, BASF, DSM, AMETEK, DuPONT, National Plastics & Seals Inc, Solvay and Polymer Technology & Services LLC.

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On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

  • PA 6
  • PA 66
  • Other

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Nylon Resins for each application, including

  • Fibers
  • Engineering Plastics
  • Packaging Films
  • Other

 

Graft Versus Host Disease GvHD Treatment Market Shares, Strategies, Analysis and Overview 2022

Graft Versus Host Disease GvHD Treatment Market
Graft Versus Host Disease GvHD Treatment Market

Graft versus Host disease happens afterward a transplantation of stem cell or bone marrow. Greater amount of treatment destroys cancer cells. Besides, it concurrently finishes fit cells. Stem cell and bone marrow transplant actions are utilized in rebuilding injured cells nearby cancer tumors. Usually after major dosage treatment, patient accepts bone marrow from a giver over drop that restarts manufacture of blood cells.  At present, graft versus host disease (GvHD) market is pushed by upsurge in amount of occurrence and commonness of cancer patients that are treated by chemotherapy treatment. Graft versus host disease (GvHD) international market is likewise powered by upsurge in amount of bone marrow relocations that have been accepted everywhere to treat exact categories of cancers. Upsurge in allogeneic hematopoietic stem cell transplant will show important role in international market for graft versus host disease (GvHD). Yet, price connected with new scientific trials and approvals would act as a main limitation to graft versus host disease (GvHD) worldwide market.

The international Graft Versus Host Disease (GvHD) Market place is sectioned into subsequent type of product, and area. By product, the market size spans Etanercept, Thalidomide, mTOR inhibitors, Tyrosine kinase inhibitors, and Monoclonal antibodies. The worldwide market graft versus host disease (GvHD) treatment is likely to record a strong CAGR in the prediction period. Inventive improvement of fresh know-hows and surge in the number of cancer patients looking for chemotherapy action are likely to push the progress of graft versus host disease (GvHD) treatment market in the prediction era (2014-2025). As per the geographical areas, global medical graft versus host disease (GvHD) treatment market is sectioned into seven main regions namely North America, Latin America, Eastern Europe, Western Europe, Asia Pacific Excluding Japan, Japan and Middle East & Africa. As per the regional division, Europe embraces the major market stake in the worldwide market graft versus host disease (GvHD) treatment. This could be attributed to developments in medicinal investigation, scientific trials, increasing elderly people with cancer symptom.

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North America and Asia Pacific are expected to nurture at a considerable development owing to great occurrence and frequency of cancer patients. The marketplace for graft versus host disease (GvHD) action in many areas is mainly motivated by progressively growing consciousness, increasing figure of chemotherapies, and acceptance of innovative machineries in cancer handling. The area wise study comprises The North America [The U.S., Canada], Latin America [Brazil, Mexico], Western Europe [England, France, Germany, Spain, Italy, Nordic countries, Belgium, The Netherlands, Luxembourg], Eastern Europe [Russia, Poland], Asia Pacific [India, China, ASEAN, Australia & New Zealand], Japan, Middle East and Africa [GCC, S. Africa, N. Africa]. The important companies that are engaged in the business of Graft versus Host Disease (GvHD) Treatment, worldwide are Mesoblast Ltd, Soligenix, Inc., Astellas Pharma Inc., Novartis AG, Merck & Co., Neovii Biotech GmbH, and Sanofi.

Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into

  • Monoclonal Antibodies
  • MTOR Inhibitors
  • Tyrosine Kinase Inhibitors
  • Thalidomide
  • Etanercept

Split by application, this report focuses on consumption, market share and growth rate of Graft Versus Host Disease GvHD Treatment in each application, can be divided into

  • Hospitals
  • Hospital Pharmacies
  • Drug Stores
  • Online Drug Stores

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Table of Contents:

1 Graft Versus Host Disease GvHD Treatment Market Overview

2 Global Graft Versus Host Disease GvHD Treatment Market Competition by Manufacturers

3 Global Graft Versus Host Disease GvHD Treatment Production, Revenue (Value) by Region (2012-2017)

4 Global Graft Versus Host Disease GvHD Treatment Supply (Production), Consumption, Export, Import by Regions (2012-2017)

5 Global Graft Versus Host Disease GvHD Treatment Production, Revenue (Value), Price Trend by Type

6 Global Graft Versus Host Disease GvHD Treatment Market Analysis by Application

7 Global Graft Versus Host Disease GvHD Treatment Manufacturers Profiles/Analysis

8 Graft Versus Host Disease GvHD Treatment Manufacturing Cost Analysis

9 Industrial Chain, Sourcing Strategy and Downstream Buyers

10 Marketing Strategy Analysis, Distributors/Traders

11 Market Effect Factors Analysis

12 Global Graft Versus Host Disease GvHD Treatment Market Forecast (2017-2022)

13 Research Findings and Conclusion

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Combination Therapy Drug Industry: Future Demand, Market Analysis & Outlook to 2022

The Global Combination Therapy Drug Market is anticipated to show a robust growth in the forthcoming years due to rising applications and scope across the globe. Combination Therapy Drug is a kind of drug that employs more than one medication. It is also popularly known as Polytherapy drug or pharmaceutical combination therapy drugs. In simple words, various therapy drugs can be used in combination in order to cure a particular disease. It is often advised to take these drugs under the doctor’s prescription. It may be costly in nature but the most striking benefits attached with the use of the drug may include lower chances of failure and less number of side effects.

Combination Therapy Drug Market
Combination Therapy Drug Market

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A wide range of diseases like Cardiovascular Disease, Cancer, Immune Disease, and many others can be treated with the help of the drug. The product is attaining huge demand and recognition across the globe due to rising prerequisites and applications. The factors responsible for the robust Combination Therapy Drug market growth may include robust industrialization, urbanization, technological improvements, prevalence of various diseases, augmented demand for effective drugs and technology, rise in the investments by leading players on research and development activities, product introductions, and rising production of combination therapy drugs. On the other hand, the factors that are acting as major obstacles in the market growth may entail soaring cost of research and development activities and lack of awareness among the consumers regarding usage of the combination therapy drugs. Combination Therapy Drug Market is divided by product type as Interferon and Nucleoside Drugs, Diammonium Glycyrrhizin ate, Targeted Therapies Drugs, and others.

Combination Therapy Drug Market is segmented on the basis of application as Immune Disease, Cardiovascular Disease, Cancer, and others. The market is classified on the basis of end users as Hospitals, Pharmaceutical and Drug Stores, Private Clinics, and others. Combination Therapy Drug industry is segregated by geography as North America, Europe, China, Japan, Southeast Asia, and India. Among all the geographical regions, it has been noticed that North America is the leader of the Combination Therapy Drug market and it will keep up its position in the market till forthcoming years, the reason being robust production, augmentation in the awareness level among the end users, rising prerequisites, mounting demands, and rise in the investments by the leading manufacturers.

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In contrast, it is likely that Europe and Asia Pacific will soon come up as one of the promising regions and show a significant rise in the Combination Therapy Drug market growth due to emergence of leading companies in these regions. The prominent companies operating in the market are recognized as Baxalta Incorporated, Bio test AG, China Biologic Products, CSL Ltd, Grifols S.A, Octapharma AG, and Kedrion S.p.A.

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

  • Diammonium Glycyrrhizin ate
  • Interferon and Nucleoside Drugs
  • Targeted Therapies Drugs
  • Others

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share and growth rate of Combination Therapy Drug for each application, including

  • Cancer
  • Cardiovascular Disease
  • Immune Disease

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Table of Contents :

1 Combination Therapy Drug Market Overview

2 Global Combination Therapy Drug Market Competition by Manufacturers

3 Global Combination Therapy Drug Capacity, Production, Revenue (Value) by Region (2012-2017)

4 Global Combination Therapy Drug Supply (Production), Consumption, Export, Import by Region (2012-2017)

5 Global Combination Therapy Drug Production, Revenue (Value), Price Trend by Type

6 Global Combination Therapy Drug Market Analysis by Application

7 Global Combination Therapy Drug Manufacturers Profiles/Analysis

8 Combination Therapy Drug Manufacturing Cost Analysis

9 Industrial Chain, Sourcing Strategy and Downstream Buyers

10 Marketing Strategy Analysis, Distributors/Traders

11 Market Effect Factors Analysis

12 Global Combination Therapy Drug Market Forecast (2017-2022)

13 Research Findings and Conclusion

Children’s Cough and Cold Medicine Market is expected to grow in the next five years

The Global Children’s Cough and Cold Medicine Market will show an exponential growth in the next couple of years due to rising prerequisites and applications. Children’s Cough and Cold Medicine is provided particularly to the children when they suffer from extreme symptoms of cold and cough. With the help of these medicines, effective relief can be offered and children can be brought back to the normal state. It helps in the treatment of sniffles and sneezes. As parents are very much concerned about their kid’s health, products are being initially checked before employment and that is why the manufacturers are developing the product adhering to various standards. It has been observed that the product is attaining huge recognition across the globe as the prerequisites among the population are rising at a significant rate.

Children_s Cough and Cold Medicine Market
Children’s Cough and Cold Medicine Market

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The factors that are playing a key role in raising the share of the Children’s Cough and Cold Medicine market may entail robust technological advancements, product developments and differentiation, constant innovations, rise in the research and development activities, growth of healthcare sector, rise in the investments by the government and leading companies, developing nations, mounting prerequisites among the population, increase in the cold and cough cases among kids, and rise in the concerns among the parents regarding their children’s health.

The only factor that may hinder the overall growth of the Children’s Cough and Cold Medicine market may include risks involved with the use of these medicines. Children’s Cough and Cold Medicine Industry is classified on the basis of product as Over-the-counter (OTC) pediatric cough and cold medicines, and others. Among all the products, it has been noticed that Over-the-counter (OTC) pediatric cough and cold medicines are mostly being preferred by the customers as it is considered to be more trustworthy and reliable.

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Children’s Cough and Cold Medicine Market is segregated by application as Commercial, Domestic, and others. The market is divided by end user as Hospitals, Children Clinics, and others. The market is segmented on the basis of geography as North America, Southeast Asia, China, Europe, Japan, and India. Among all the geographical regions, it has been observed that the North America is lately been considered as the leader of the Children’s Cough and Cold Medicine market and it is simultaneously holding the largest share in the market. The factors that can be attributed to the particular growth of the region may include augmented awareness among the end users, and rise in the product innovations by the leading companies.

On the other hand, Asia Pacific and Europe are also showing a considerable rate due to rise in the Children’s Cough and Cold Medicine market growth opportunities in these regions. The prominent players operating in the Children’s Cough and Cold Medicine Market are recognized as Cold-Eeze, Dimetapp, Claritin, Frida Baby, Grac, Robitussin , Similasan, Simply Saline, Sudafed, NatraBio, NeilMed, PediaCare, ZarBee’s Naturals, Dr. Cocoa, Allegra, Homeolab USA, Hyland’s, Little Remedies, Ayr, BabyComfyNose, Triaminic, Vicks, Walgreens, Zicam, Mentholatum, Mucinex, Advil, Benadryl, and Boiron.

On the basis of product, this report displays the production, revenue, price, market share and growth rate of each type, primarily split into

By Type

  • Dishes Grinding Bowl
  • Food Mill Bowl

By Materials

  • PP
  • Metal
  • ABS
  • Plastic
  • PET
  • Silicone

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Table of Contents :

1 Children’s Cough and Cold Medicine Market Overview

2 Global Children’s Cough and Cold Medicine Market Competition by Manufacturers

3 Global Children’s Cough and Cold Medicine Capacity, Production, Revenue (Value) by Region (2012-2017)

4 Global Children’s Cough and Cold Medicine Supply (Production), Consumption, Export, Import by Region (2012-2017)

5 Global Children’s Cough and Cold Medicine Production, Revenue (Value), Price Trend by Type

6 Global Children’s Cough and Cold Medicine Market Analysis by Application

7 Global Children’s Cough and Cold Medicine Manufacturers Profiles/Analysis

8 Children’s Cough and Cold Medicine Manufacturing Cost Analysis

9 Industrial Chain, Sourcing Strategy and Downstream Buyers

10 Marketing Strategy Analysis, Distributors/Traders

11 Market Effect Factors Analysis

12 Global Children’s Cough and Cold Medicine Market Forecast (2017-2022)

13 Research Findings and Conclusion

Automobile Engine Valve Market to 2021 Industry Size, Share, Revenue Analysis

Automobile Engine Valve Market
Automobile Engine valve Market

Valves are pipeline fittings which are used to regulate fluid and liquid flows. Valves have multiple applications in end-use industries such as commercial, industrial, automobiles, military, and residential establishments. This report description focuses on automotive valves. These valves have wide applications in water pipes, tires, and engines. Auto valves of varied dimensions and sizes are used in most vehicles types such as trucks, cars, two wheelers, aircraft, and tractors. A gamut of automotive valves of different materials is offered by global suppliers of automotive valves. Raw materials used in automobiles valves include materials such as galvanized iron, stainless steel, copper, brass, caste steel, carbon steel, bronze and aluminum. Automobile engine valve works by allowing a mixture into the inlet cylinder. This further helps the spent gases to escape in the form of exhaust valve. Automotive engine valves are designed for precise opening and closing owing to smooth engine run at any given speed. Some of the key components of automobile engine valves include crankshaft, spear-rods and others.

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The global landscape of the automotive valve engine market from various industry and automotive association reports stated that in the past decade suppliers from North America faced challenges in supplying components and automobile parts owing to input cost which rose steeply. However market dynamics such as intense competition owing to globalization, declining profitability, increasing prices, have hindered the market growth. However increased automobile activities from Asia-Pacific regions especially in the countries from India, China, Japan, Thailand and Malaysia are expected to boost the Global Automobile Engine valve Market growth. Other key drivers identified to boost the global automobile engine valve include increasing growth of automobile aftermarket sales, higher demand for automobile components, and increasing demand for automobile engine valves oil and lubricants owing to its properties such as reduction of wear and tear on moving parts, resistance to corrosion, engine coolant, sealing improvement, oxidation inhibition, minimization of oil-sludge, minimization of adverse effect on catalytic converters and others.

The global automobile engine valves are segmented based on types of cycles, types of fuel used, number of cylinders, arrangement of cylinders, firing order, arrangement of valves, type of cooling, rotary or reciprocating engines. The types of cycles generally include four stroke or two stroke. Based on types of fuels the global market is segmented on the basis of diesel, CNG an d petrol. On the basis of number of cylinders the passenger car engines include four, three, six, five, twelve and eight engines. Generally buses and trucks have sixteen and twelve cylinder engines. Increasing demand for heavy commercial vehicles and passenger cars are also expected to boost the global automobile engine vehicles market. Crankshaft is the key component of the engine valve on the basis of firing order. Increasing demand and supply of automobile crankshaft component parts from automotive end-users is also expected to boost the future market growth.

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Key industry players in the market include Federal-Mogul (TRW), Eaton, MAHLE, Fuji Oozx, Rane, Nittan, AISAN, SSV Valves, Burg, Ferrea, SINUS, Dengyun Auto-parts, Worldwide Auto-Accessory, Sheng Chi Auto Parts, Yangzhou Guanghui , Wode Valve, Xin Yue Automotive, AnFu, JinQingLong , Tyen Machinery, Tongcheng, Nextech Engineering, Hitachi Automotive Systems, Cummins Inc., NHK Spring Co., Nemak, Keco Auto Industries, Saini India Pvt.Ltd., Avrand Plastic Co. Ltd., Anqing Dingli Auto parts Co. Ltd., Chon Pin Enterprist Co. Ltd., Contranspower Co. Ltd., Chaid Neme Hermanos, China Lutong Parts Plant, Chongqing Dadong Longteng Automobile & Motorcycle Valve Manufacturing Co., Ltd., DM Ruver, Dokumtek, European Truck Camion Technic, East Lake Auto Parts Co., Ltd., Eastern Auto Traders, Guanzhou Hengzhou Auto Parts Co., Ltd., Guangzhou Master Industrial Co.Ltd., Gulf Marine International, Gunes Motor Supaplari San. Ve. Tic. A.S, Hebei Zhonghao Steel, Henweit Engine Parts Co., Ltd., HPV, JNJ Industrial Co. Ltd and others.

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2,3-Dichloropyridine Market Share, Growth, Demand & Outlook From 2011-2021

Global 2,3-Dichloropyridine Market demand is expected to witness a steady growth on account of its increasing application in the manufacturing of insecticides and fungicides. Dichloropyridrine is an organic compound with a chemical formula C5H3Cl2N. It is a white to yellowish crystalline powder and slightly soluble in water. It is produced through chlorination of 2,6 Dichloropyridrine followed by hydrogenation in an organic solvent with the help of acid binding catalyst. This compound acts as an intermediate for further synthesis of pyridine derivative mainly in the agrochemical manufacturing. It is mainly used in the production of insecticides, fungicides, food flavorings, feed additives, disinfectants and adhesives. Usage of 2,3-Dichloropyridineas a raw material is a major application driving the overall demand. This compound is used in the manufacturing of pesticides and insecticides. These agro chemicals are widely used to increase the crop yield. Growing demand from agro chemical industry provides great opportunities in near future.

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Further, 2,3-Dichloropyridineis used as an intermediate for pharmaceutical drugs which has been driving the market demand in recent years. Drugs such as Betrixaban used for prevention of embolism after knee surgery makes use of Dichloropyridrine as a raw material. Government regulations and safety related to this organic compound offers a major challenge for the overall industry growth. The Global harmonized system of classification (GHS) categorizes it as 2 and 2B. Its usage as safe when used in proper quantities and with adequate safety measures but offers risk as a skin irritant and eye irritant. This chemical is considered non-hazardous for transport through air or sea. Vendors face a threat owing to the backward integration possibilities by the larger agro chemical manufacturers.

2,3-Dichloropyridine Market
2,3-Dichloropyridine Market

Market segmentation is done on the basis of end use industries which include agrochemical manufacturing and pharmaceuticals. Agro chemicals account for maximum segment share owing to its high usage in pesticides and insecticides. China is a leading producer of agro chemicals and contributes towards the majority share. Asia Pacific has been the leading market in recent years in terms of demand and is expected to continue its increasing application in agro chemical production. China has shown substantial production and consumption of 2,3-Dichloropyridinefor manufacturing pesticides and insecticides. Emerging economies such as India and China are expected to witness a significant growth on account of high investment in organic chemical manufacturing.

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Further, regional demand is followed by North America mainly on account of increasing use of pharmaceutical. Development of new drugs has fueled the demand in developed economy such as the US. Europe is expected to show a steady growth over the forecast period with increasing demand on account of pharmaceutical applications. South America and Africa is expected to witness a stagnant growth owing to the slow growth of overall development of application industries.  Major players operating in the market are Vertellus, Lonza and Jubilant. Companies are focusing on research and development in order to find out new applications for 2,3-Dichloropyridine. This is expected to diversify the application portfolio and therefore propelling the demand in near future.